Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.4
USERS' SCORE
Good
Based on 8 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
9
Fish oil improves knee function
We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
Read More
We explored the impacts of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on knee pain and inflammation in a mouse model of knee arthritis. Our objective was to see if DHA could ease spontaneous pain, reduce swelling, and improve mobility in mice that had been induced with arthritis using Complete Freund's Adjuvant (CFA).
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Read More
7
We set out to investigate how a compound called 17-HDHA, a precursor to docosahexaenoic acid (DHA), influences knee pain in people suffering from osteoarthritis. Our research involved two groups: healthy volunteers and individuals with knee osteoarthritis.
We measured levels of 17-HDHA and several other resolvins in participants and assessed their heat pain sensitivity as well as their knee pain. Interestingly, we found that higher levels of 17-HDHA were linked to increased heat pain thresholds, meaning individuals felt less pain when exposed to heat. Moreover, knee osteoarthritis patients with higher levels of 17-HDHA reported lower pain scores, suggesting a potential analgesic effect.
However, it's important to note that the other resolvins tested, including D-series and E-series resolvins, did not show a significant association with either heat pain sensitivity or osteoarthritis pain. Additionally, the effects of 17-HDHA appeared to be independent of DHA levels in the body. This suggests that 17-HDHA itself may play a crucial role in managing knee pain in osteoarthritis patients.
We measured levels of 17-HDHA and several other resolvins in participants and assessed their heat pain sensitivity as well as their knee pain. Interestingly, we found that higher levels of 17-HDHA were linked to increased heat pain thresholds, meaning individuals felt less pain when exposed to heat. Moreover, knee osteoarthritis patients with higher levels of 17-HDHA reported lower pain scores, suggesting a potential analgesic effect.
However, it's important to note that the other resolvins tested, including D-series and E-series resolvins, did not show a significant association with either heat pain sensitivity or osteoarthritis pain. Additionally, the effects of 17-HDHA appeared to be independent of DHA levels in the body. This suggests that 17-HDHA itself may play a crucial role in managing knee pain in osteoarthritis patients.
Read More
Most Useful Reviews
7.5
Improved joint flexibility
730 people found this helpful
In my opinion, this is the best Omega 3 on the site; I only buy it in triglyceride form. It’s made from the carcasses of cold-water fish with a short life cycle and has a high concentration of polyunsaturated fatty acids EPA and DHA. The right fats help strengthen the immune system, improve brain activity, and benefit the skin, nails, and hair. From taking it, I’ve noticed an improvement in my knee joints (it’s easier to bend and unbend), and my skin has become more hydrated and elastic. There’s no aftertaste or unpleasant sensations. I feel better. A quality brand; I recommend it!
Read More
9
Knee joints improved
87 people found this helpful
The best Omega 3 on the site! I consistently purchase this product. It fulfills all necessary requirements for an effective and pure omega-3: triglyceride form, sourced from cold-water fish carcasses with a short life cycle, containing a high concentration of EPA and DHA, and a high degree of purification from harmful substances. It’s gentle on the stomach and doesn’t cause belching. I’ve noticed an improvement in my knee joints (it’s easier to bend and unbend), and my skin is now more moisturised and elastic. I’m very pleased with this product!
Read More
7.5
Joint pain reduced
72 people found this helpful
Elite omega-3! This is the best Omega 3 I’ve found; I buy it consistently. It meets all requirements for an effective omega-3: triglyceride form, sourced from cold-water fish carcasses, high in EPA and DHA, highly purified, and easily absorbed by the stomach without causing belching. I’ve noticed a marked improvement in my knee joints (it’s easier to bend and unbend), and my skin is now more hydrated and elastic. Definitely beneficial!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.4
- All Researches
9
Eicosapentaenoic Acid Reduces Knee Pain
We conducted a study to investigate how eicosapentaenoic acid (EPA), a component of omega-3 fatty acids, impacts knee pain in healthy adults over the age of 40 with persistent discomfort. The study was structured as a randomized, double-blind, controlled clinical trial, which means that participants were assigned to either an EPA product or a placebo without knowing which they were receiving.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.
Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.
However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Read More
9
We conducted a comprehensive study involving 177 patients with moderate to severe osteoarthritis (OA) affecting their hips or knees. Over 26 weeks, participants were divided into two groups. One group received glucosamine sulfate combined with omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The other group was treated with glucosamine sulfate alone.
Our main focus was to determine whether the combined treatment provided any notable benefits over glucosamine alone when it came to easing knee pain. We used the WOMAC score to assess pain, stiffness, and overall function in the participants. When we looked at the significant reduction of pain, more than 92% from both groups experienced some relief, but the combination treatment showed a higher response rate of 44%, compared to 32% in the glucosamine-only group.
Although both treatments appeared safe over the study duration, the statistical differences indicate that adding omega-3s can be beneficial for those specifically hoping for greater relief. We also noted that symptoms like morning stiffness and knee pain showed improvements, with greater reductions in the group taking the combination treatment. This suggests that eicosapentaenoic acid may provide added value in managing knee pain due to osteoarthritis, particularly for patients looking to maximize their treatment benefits.
Our main focus was to determine whether the combined treatment provided any notable benefits over glucosamine alone when it came to easing knee pain. We used the WOMAC score to assess pain, stiffness, and overall function in the participants. When we looked at the significant reduction of pain, more than 92% from both groups experienced some relief, but the combination treatment showed a higher response rate of 44%, compared to 32% in the glucosamine-only group.
Although both treatments appeared safe over the study duration, the statistical differences indicate that adding omega-3s can be beneficial for those specifically hoping for greater relief. We also noted that symptoms like morning stiffness and knee pain showed improvements, with greater reductions in the group taking the combination treatment. This suggests that eicosapentaenoic acid may provide added value in managing knee pain due to osteoarthritis, particularly for patients looking to maximize their treatment benefits.
Read More
9
Fish oil improves knee function
We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
Read More
We explored the impacts of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on knee pain and inflammation in a mouse model of knee arthritis. Our objective was to see if DHA could ease spontaneous pain, reduce swelling, and improve mobility in mice that had been induced with arthritis using Complete Freund's Adjuvant (CFA).
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Read More
8
We explored the potential benefits of eicosapentaenoic acid (EPA) combined with l-serine in relieving chronic low-back and knee pain among adults. In a well-structured randomized, double-blind, placebo-controlled trial, we followed 120 participants who suffered from pain for over three months. They were divided into two groups: one received daily doses of 594 mg of l-serine and 149 mg of EPA, while the other group was given a placebo.
After eight weeks of treatment and a four-week follow-up, we observed pain relief improvements reported through various questionnaires. The results indicated that the combination of l-serine and EPA was effective in reducing pain in the lower back and knees, highlighting the significance of these components in managing chronic pain conditions. Though EPA was part of a combination treatment, its anti-inflammatory properties may offer a promising avenue for individuals suffering from knee pain specifically.
Our findings provide an encouraging perspective for those seeking alternatives for pain management. While the study combined l-serine with EPA, it became evident that these ingredients together can lead to meaningful relief for patients with persistent knee pain.
After eight weeks of treatment and a four-week follow-up, we observed pain relief improvements reported through various questionnaires. The results indicated that the combination of l-serine and EPA was effective in reducing pain in the lower back and knees, highlighting the significance of these components in managing chronic pain conditions. Though EPA was part of a combination treatment, its anti-inflammatory properties may offer a promising avenue for individuals suffering from knee pain specifically.
Our findings provide an encouraging perspective for those seeking alternatives for pain management. While the study combined l-serine with EPA, it became evident that these ingredients together can lead to meaningful relief for patients with persistent knee pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved joint flexibility
730 people found this helpful
In my opinion, this is the best Omega 3 on the site; I only buy it in triglyceride form. It’s made from the carcasses of cold-water fish with a short life cycle and has a high concentration of polyunsaturated fatty acids EPA and DHA. The right fats help strengthen the immune system, improve brain activity, and benefit the skin, nails, and hair. From taking it, I’ve noticed an improvement in my knee joints (it’s easier to bend and unbend), and my skin has become more hydrated and elastic. There’s no aftertaste or unpleasant sensations. I feel better. A quality brand; I recommend it!
Read More
9
Knee joints improved
87 people found this helpful
The best Omega 3 on the site! I consistently purchase this product. It fulfills all necessary requirements for an effective and pure omega-3: triglyceride form, sourced from cold-water fish carcasses with a short life cycle, containing a high concentration of EPA and DHA, and a high degree of purification from harmful substances. It’s gentle on the stomach and doesn’t cause belching. I’ve noticed an improvement in my knee joints (it’s easier to bend and unbend), and my skin is now more moisturised and elastic. I’m very pleased with this product!
Read More
7.5
Joint pain reduced
72 people found this helpful
Elite omega-3! This is the best Omega 3 I’ve found; I buy it consistently. It meets all requirements for an effective omega-3: triglyceride form, sourced from cold-water fish carcasses, high in EPA and DHA, highly purified, and easily absorbed by the stomach without causing belching. I’ve noticed a marked improvement in my knee joints (it’s easier to bend and unbend), and my skin is now more hydrated and elastic. Definitely beneficial!
Read More
9
Elastic skin regained
53 people found this helpful
Very good omega-3! This is my preferred Omega 3, which I buy repeatedly. It meets important criteria for a pure omega-3: triglyceride form, from cold-water fish carcasses, high concentrations of EPA and DHA, and highly purified. It’s easily absorbed, with no belching. I’ve observed improvements in my knee joints (it’s easier to bend and unbend) and my skin has become more hydrated and elastic. I’m very pleased with the results and recommend it!
Read More
10
Knee joint reduction
1 people found this helpful
Despite its high price, its effectiveness is remarkable; the severity of my knee joints has significantly reduced. Thanks, Iherb. Grateful to Rserch Sport for providing this excellent product.
Read More
Frequently Asked Questions
10
Knee joint reduction
1 people found this helpful
Despite its high price, its effectiveness is remarkable; the severity of my knee joints has significantly reduced. Thanks, Iherb. Grateful to Rserch Sport for providing this excellent product.
7.5
Improved joint flexibility
730 people found this helpful
In my opinion, this is the best Omega 3 on the site; I only buy it in triglyceride form. It’s made from the carcasses of cold-water fish with a short life cycle and has a high concentration of polyunsaturated fatty acids EPA and DHA. The right fats help strengthen the immune system, improve brain activity, and benefit the skin, nails, and hair. From taking it, I’ve noticed an improvement in my knee joints (it’s easier to bend and unbend), and my skin has become more hydrated and elastic. There’s no aftertaste or unpleasant sensations. I feel better. A quality brand; I recommend it!
7.5
Joint pain reduced
72 people found this helpful
Elite omega-3! This is the best Omega 3 I’ve found; I buy it consistently. It meets all requirements for an effective omega-3: triglyceride form, sourced from cold-water fish carcasses, high in EPA and DHA, highly purified, and easily absorbed by the stomach without causing belching. I’ve noticed a marked improvement in my knee joints (it’s easier to bend and unbend), and my skin is now more hydrated and elastic. Definitely beneficial!
9
Easier joint movement
2 people found this helpful
Excellent composition; I only need one capsule per day. This is the best Omega-3 I've found, made from cold water fish with a high concentration of EPA and DHA. The right fats not only enhance immune function but also improve brain activity and skin quality. Since I started taking it, my knee joints feel easier to bend, and I’ve noticed improvements in skin hydration. There’s no aftertaste, and I feel much better. A quality brand that I highly recommend!
9
Knee joints improved
87 people found this helpful
The best Omega 3 on the site! I consistently purchase this product. It fulfills all necessary requirements for an effective and pure omega-3: triglyceride form, sourced from cold-water fish carcasses with a short life cycle, containing a high concentration of EPA and DHA, and a high degree of purification from harmful substances. It’s gentle on the stomach and doesn’t cause belching. I’ve noticed an improvement in my knee joints (it’s easier to bend and unbend), and my skin is now more moisturised and elastic. I’m very pleased with this product!
9
Elastic skin regained
53 people found this helpful
Very good omega-3! This is my preferred Omega 3, which I buy repeatedly. It meets important criteria for a pure omega-3: triglyceride form, from cold-water fish carcasses, high concentrations of EPA and DHA, and highly purified. It’s easily absorbed, with no belching. I’ve observed improvements in my knee joints (it’s easier to bend and unbend) and my skin has become more hydrated and elastic. I’m very pleased with the results and recommend it!
6
Reduced knee pain
A very good composition is triglycerides, not an ethyl ester form. The hair has become smoother, and there are no reactions from my body. I previously took Nordic Naturals, which caused fishy belches and heartburn. This omega is well tolerated. I take it with vitamin D and the Eva complex from Now, and I've found that my knees seem to have stopped hurting. The capsules are large, but they're easy enough to swallow.
7
Krill oil improves knee OA symptoms
We examined how krill oil, which contains eicosapentaenoic acid (EPA), impacts knee pain in adults suffering from mild to moderate osteoarthritis (OA). In a well-structured study, 235 participants were involved in a six-month, double-blind, placebo-controlled trial, allowing us to see the real effects of krill oil compared to a placebo.
The participants took either 4 grams of krill oil daily or a placebo, and we assessed their knee pain and function at the beginning, three months, and six months into the study. The results revealed that krill oil led to modest improvements in knee pain, stiffness, and physical function.
Although the study showed positive results, it's important to note that we couldn’t isolate the specific impacts of eicosapentaenoic acid alone, since it was part of a complex oil supplement. Overall, this suggests that krill oil could be a safe and beneficial option for managing knee OA symptoms, but specific effects of EPA remain unclear.
The participants took either 4 grams of krill oil daily or a placebo, and we assessed their knee pain and function at the beginning, three months, and six months into the study. The results revealed that krill oil led to modest improvements in knee pain, stiffness, and physical function.
Although the study showed positive results, it's important to note that we couldn’t isolate the specific impacts of eicosapentaenoic acid alone, since it was part of a complex oil supplement. Overall, this suggests that krill oil could be a safe and beneficial option for managing knee OA symptoms, but specific effects of EPA remain unclear.
9
We conducted a comprehensive study involving 177 patients with moderate to severe osteoarthritis (OA) affecting their hips or knees. Over 26 weeks, participants were divided into two groups. One group received glucosamine sulfate combined with omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The other group was treated with glucosamine sulfate alone.
Our main focus was to determine whether the combined treatment provided any notable benefits over glucosamine alone when it came to easing knee pain. We used the WOMAC score to assess pain, stiffness, and overall function in the participants. When we looked at the significant reduction of pain, more than 92% from both groups experienced some relief, but the combination treatment showed a higher response rate of 44%, compared to 32% in the glucosamine-only group.
Although both treatments appeared safe over the study duration, the statistical differences indicate that adding omega-3s can be beneficial for those specifically hoping for greater relief. We also noted that symptoms like morning stiffness and knee pain showed improvements, with greater reductions in the group taking the combination treatment. This suggests that eicosapentaenoic acid may provide added value in managing knee pain due to osteoarthritis, particularly for patients looking to maximize their treatment benefits.
Our main focus was to determine whether the combined treatment provided any notable benefits over glucosamine alone when it came to easing knee pain. We used the WOMAC score to assess pain, stiffness, and overall function in the participants. When we looked at the significant reduction of pain, more than 92% from both groups experienced some relief, but the combination treatment showed a higher response rate of 44%, compared to 32% in the glucosamine-only group.
Although both treatments appeared safe over the study duration, the statistical differences indicate that adding omega-3s can be beneficial for those specifically hoping for greater relief. We also noted that symptoms like morning stiffness and knee pain showed improvements, with greater reductions in the group taking the combination treatment. This suggests that eicosapentaenoic acid may provide added value in managing knee pain due to osteoarthritis, particularly for patients looking to maximize their treatment benefits.
9
Fish oil improves knee function
We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
References
- Pérez-Piñero S, Muñoz-Carrillo JC, Victoria-Montesinos D, García-Muñoz AM, Andreu-Caravaca L, et al. Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial. Nutrients. 2023;15. doi:10.3390/nu15173848
- Kubo Y, Ikeya M, Sugiyama S, Takachu R, Tanaka M, et al. Effects of n-3 polyunsaturated fatty acid supplementation on quadriceps weakness immediately after total knee arthroplasty: a pilot, randomized, open-label clinical trial. J Phys Ther Sci. 2023;35:93. doi:10.1589/jpts.35.93
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2022;116:672. doi:10.1093/ajcn/nqac125
- Sasahara I, Yamamoto A, Takeshita M, Suga Y, Suzuki K, et al. l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Nutr. 2020;150:2278. doi:10.1093/jn/nxaa156
- Kubo Y, Sugiyama S, Takachu R, Tanaka M, Ikeya M, et al. Association between serum n-3 polyunsaturated fatty acids and quadriceps weakness immediately after total knee arthroplasty. PLoS One. 2020;15:e0228460. doi:10.1371/journal.pone.0228460
- Gruenwald J, Petzold E, Busch R, Petzold HP, Graubaum HJ. Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis. Adv Ther. 2009;26:858. doi:10.1007/s12325-009-0060-3
- Iverson C, Bacong A, Liu S, Baumgartner S, Lundström T, et al. Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation. Sci Rep. 2018;8:1217. doi:10.1038/s41598-018-19252-x
- Valdes AM, Ravipati S, Menni C, Abhishek A, Metrustry S, et al. Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans. Sci Rep. 2017;7:10748. doi:10.1038/s41598-017-09516-3
- Huang J, Burston JJ, Li L, Ashraf S, Mapp PI, et al. Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain. Arthritis Rheumatol. 2017;69:996. doi:10.1002/art.40001
- Barden AE, Moghaddami M, Mas E, Phillips M, Cleland LG, et al. Specialised pro-resolving mediators of inflammation in inflammatory arthritis. Prostaglandins Leukot Essent Fatty Acids. 2016;107:24. doi:10.1016/j.plefa.2016.03.004
- Peanpadungrat P. Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis. J Med Assoc Thai. 2015;98 Suppl 3:S110.
- Torres-Guzman AM, Morado-Urbina CE, Alvarado-Vazquez PA, Acosta-Gonzalez RI, Chávez-Piña AE, et al. Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritis. Arthritis Res Ther. 2014;16:R64. doi:10.1186/ar4502
